Ongoing/not yet reported trials
There are excellent summaries on the ACPGBI’s website: https://www.acpgbi.org.uk/research/trials/
Key published colorectal papers
Dutch TME trial
An RCT to determine whether the addition of preoperative radiotherapy increases the benefit of total mesorectal excision
https://www.nejm.org/doi/full/10.1056/NEJMoa010580
The German CAO/ARO/AIO-94 trial
A randomized phase III Trial of preoperative chemoradiotherapy vs. postoperative chemoradiotherapy for locally advanced rectal cancer.
https://www.nejm.org/doi/pdf/10.1056/NEJMoa040694
The Ladies trial
An RCT of management in acute diverticulitis.
Aims to determine whether LaparOscopic LAvage and drainage is a safe and effective treatment for patients with purulent peritonitis (LOLA-arm) and to determine the optimal resectional strategy in patients with a purulent or faecal peritonitis (DIVA-arm: perforated DIVerticulitis: sigmoidresection with or without Anastomosis).
https://link.springer.com/article/10.1186/1471-2482-10-29
The MERCURY study
Study of accuracy, feasibility and reproducibility of Magnetic Resonance Imaging (MRI) to stage rectal cancer
https://www.ncbi.nlm.nih.gov/pubmed/17329685
The MRC CR07 trial
A trial of preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60484-0/abstract
The QUASAR study
A trial to determine the size and duration of any survival benefit from adjuvant chemotherapy for patients with colorectal cancer at low risk of recurrence, for whom the indication for such treatment is unclear.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)61866-2/abstract
The MRC CLASICC trial
A trial of open versus laparoscopic surgery for colorectal cancer